Arizona Sen. John McCain has a brain tumor, the Mayo Clinic Hospital in Phoenix announced on Wednesday.

The announcement follows a procedure that McCain, 80, had on July 14 in which he had a blood clot removed from above his left eye.

"Further consultations with Senator McCain's Mayo Clinic care team will indicate when he will return to the United States Senate," his office said in a statement.

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"Subsequent tissue pathology revealed that a primary brain tumor known as a glioblastoma was associated with the blood clot," the hospital said.

“Scanning done since the procedure (a minimally invasive craniotomy with an eyebrow incision) shows that the tissue of concern was completely resected by imaging criteria.

“The Senator and his family are reviewing further treatment options with his Mayo Clinic care team. Treatment options may include a combination of chemotherapy and radiation."

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McCain ran for president twice. He lost the GOP nomination to George W. Bush in 2000 and was the Republican nominee in the 2008 election before losing to Barack Obama in the general election.

“John McCain is a hero to our Conference and a hero to our country," Senate Majority Leader Mitch McConnell said in a statement. "He has never shied from a fight and I know that he will face this challenge with the same extraordinary courage that has characterized his life. The entire Senate family’s prayers are with John, Cindy and his family, his staff, and the people of Arizona he represents so well."

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“We all look forward to seeing this American hero again soon,” McConnell said.

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